Mesoporous Bioactive Glass Nanoparticles (MBGNs) give the intrinsic properties of biocompatibility and biodegradability, and it is the promising approach to the delivery of elemental ions. The Boron (B) ions highlight angiogenic potential [1], addressing the vascular deficit in non-healing wounds, an essential stride in biomaterial-enhanced chronic wound healing. Silver (Ag) ions are considered for their antibacterial effect against the gram-positive and gram-negative strains [2] . The integration of B and Ag in MBGNs further refines the biomaterial strategy, presenting a novel approach to optimizing angiogenesis for enhanced wound healing and bactericidal activity. These B-Ag doped MBGNs were synthesized using modified Stöber method. The incorporation of B in MBGNs demonstrated a profound impact on their physicochemical properties, resulting in promoting vessel growth and non-cytotoxicity. The Ag provides anti-bacterial properties that help the glass resist infection and inflammation. The prepared B-Ag doped MBGNs shows the 100-300 nm of sphere size with the pore size varied from 2nm to 10nm and the Scanning Electron Microscopy (SEM) also confirms the mesoporous structures of MBGNs and adsorption of B and Ag on the outer surface of the MBGNs, X-ray diffraction (XRD) proved that the crystallinity and presence of B and Ag in the MBGNs, while EDS analysis results are also in the agreement with XRD, Fourier transform Infrared (FTIR) Spectroscopy shows the peak of silica, B and Ag 723 cm^-1, 1005 cm^-1 , 1631 cm^-1 respectively. In-vivo Chorioallantoic Membrane (CAM) assay reported the angiogenic potential of the B in B-Ag MBGNs, cyto-compatibility were analyzed through the WST-8 and results show the non-toxicity of B and Ag. This research provides valuable insights into the potential of B and Ag doped MBGNs as promising wound healing materials with all round benefits, and antibacterial properties.

Azaz Haider

Appearances