Division/Committee: [BIOT] Division of Biochemical Technology

Membrane-based separation techniques are essential for processing of a wide range of biopharmaceutical and biochemical products including small molecules, monoclonal antibodies, vaccines, viral vectors, etc. These techniques are utilized in a wide range of applications in bioprocessing from cell harvest/clarification to virus removal, and product purification, concentration, and buffer exchange. Membrane-based techniques enable and complement many key and novel separations required for purification of biomolecules and are being actively studied and improved in order to meet a higher demand for performance, such as effective harvesting of higher density cell cultures, high-throughput virus filters, high-concentration formulation development, and/or integration of unit operations for continuous/semi-continuous manufacturing. These technologies also play a key role in identifying novel ways of using conventional unit operations to solve both current and future bioprocessing challenges of complex biological products such as use of new/modified membrane material and novel modes of operation. This session seeks to focus on process understanding surrounding membrane operations and to report advances in the development, fundamental understanding, industrial application, and novel implementations of membrane-based unit operations to achieve desired bioseparations. Operations of interest include traditional and novel filtration and membrane processes for clarification, bioburden reduction, virus removal, ultrafiltration and diafiltration, formulation, etc. Both experimental and modeling (mechanistic, statistical, hybrid, etc.) submissions are welcome to this session. Priority will be given to those presentations that provide insights and present approaches of general utility, and for which experimental and/or manufacturing implementations are presented and compared with alternative approaches.

Abhijeet Shirke

Associate Director, Process Development, Teva Pharmaceuticals

Appearances