Christopher Mussari

Dimeric antagonists of endosomal toll-like receptors 7, 8 and 9 (TLR7/8/9)
Optimization of indole-based antagonists of toll-like receptors 7 and 8 (TLR7/8) through C-2 variations
Discovery of afimetoran, a small molecule dual antagonist of the toll-like receptors 7 and 8 (TLR7/8) advanced to clinical evaluation in patients with lupus
Identification of 2-pyridinyl-indoles as selective dual antagonists of the toll-like receptors 7 and 8 (TLR7/8) for the treatment of autoimmune diseases
Discovery of selective small-molecule dual antagonists of toll-like receptors 7 and 8 (TLR7/8) through optimization of an indole scaffold and C-2 bicyclic heteroarene substituents

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