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John Gilmore
Appearances
Structure-based design of 2-(pyridin-2(1H)-one)indoles as antagonists of the toll-like receptors TLR7 and TLR8 for the treatment of autoimmune diseases
Dimeric antagonists of endosomal toll-like receptors 7, 8 and 9 (TLR7/8/9)
Optimization of indole-based antagonists of toll-like receptors 7 and 8 (TLR7/8) through C-2 variations
Structure-based design of 2-(pyridin-2(1H)-one)indoles as antagonists of the toll-like receptors TLR7 and TLR8 for the treatment of autoimmune diseases
Discovery of afimetoran, a small molecule dual antagonist of the toll-like receptors 7 and 8 (TLR7/8) advanced to clinical evaluation in patients with lupus
Discovery of selective small-molecule dual antagonists of toll-like receptors 7 and 8 (TLR7/8) through optimization of an indole scaffold and C-2 bicyclic heteroarene substituents
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